Late Effects in Children with Wilms Tumor Treated on the COG ARENO Studies

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Consortium PI: Peter Ehrlich, MD

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The survival rate for children with renal tumors now exceeds 85%. As a result, recent studies have shifted their focus to addressing the long-term impacts of therapy. The National Wilms Tumor Studies 1–5 (NWTSG) documented significant late events and effects of treatment. The Children’s Oncology Group Renal Tumor (ARENO) studies were designed not only to improve event-free and overall survival, but also to develop regimens that reduce the late events and effects previously reported in the NWTSG studies...

 

 

The Applicability of Recommendations Resulting from Ultrasonographic BI-RADS Classification in Adolescent Females

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Consortium PIs: Barrie Rich, MD and Sara Mansfield, MD

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Breast masses can be present in >3% of adolescent patients but are rarely malignant. The American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) is an adult-validated system used to standardize the assessment of breast masses and their appearance on mammography, ultrasound and MRI to risk-stratify these lesions. Masses which are determined to be BI-RADS 4 and above are suspicious for malignancy and recommended for tissue biopsy...

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Multimodal Treatment of Desmoplastic Small Round Cell Tumors

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Consortium PIs: Tim Lautz, MD and Roshni Dasgupta, MD, MPH

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Desmoplastic small round cell tumor (DSRCT) is a rare soft tissue sarcoma characterized by a unique EWS-WT1 translocation. Unfortunately, DSRCT is often asymptomatic until advanced stages and associated with high mortality rates. Treatment regimens are multimodal, involving chemotherapy and cytoreductive surgery (CRS) often combined with whole abdomen radiation (WART) and/or heated intraperitoneal chemotherapy (HIPEC)...​​​​​