The care of most children with cancer is multimodal, with surgery playing an important role alongside chemotherapy and radiation therapy. However, the primary focus of most childhood cancer research has been on improving chemotherapy regimens. The Pediatric Surgical Oncology Research Collaborative (PSORC) therefore aims to resolve key unanswered questions related to the surgical care of children and adolescents with extracranial solid tumors. Our mission is to improve the surgical outcomes for children and adolescents with cancer through the multi-institutional collaborative investigation of surgical approaches to malignant disease.