Unfortunately, nearly 1 out of every 6000 children and adolescents will develop cancer.  While a number of national and international organizations are committed to advancing the care of these children, their primary focus is on optimizing and improving chemotherapy regimens.  However, the care of most children with cancer is multi-modal, with surgery and/or radiation therapy playing an important role alongside chemotherapy.  By combining efforts from dozens of major pediatric institutions across North America, the Pediatric Surgical Oncology Research Collaborative is hoping to resolve key unanswered questions related to the surgical care of these children, and in doing so, improve both their oncologic outcomes and quality of life.