Neuroblastoma is the most common extracranial pediatric solid tumor, affecting almost 1 in every 10,000 live births. Neuroblastoma is an extremely heterogeneous tumor. Clinical presentations that range from regression and complete resolution without intervention to aggressive disease with a high propensity for metastases and poor survival rates persist despite intensive multimodality treatment. With improvements in the care for patients with neuroblastoma, survival and outcomes for low and intermediate-risk neuroblastoma have similarly improved. However, survival remains around 50% for children with high-risk disease despite multimodal treatments, including chemotherapy, radiation, surgery, and stem-cell transplant. Furthermore, survivors often experience debilitating side effects from treatment. There is a significant unmet need for research investigating optimal care for pediatric patients with neuroblastoma, a common and often devastating childhood cancer.
Study Aims:
Identify associations between patient demographics and short- and long-term outcomes in children with neuroblastoma.
Identify patient and perioperative factors associated with surgical complications and oncologic outcomes following neuroblastoma resection.
Determine the impact of surgical complications on the overall care and outcomes of children with neuroblastoma.
Contact Chloe Boehmer (Chloe.Boehmer@cchmc.org) for information on how your site can participate.
